Palliative first-line treatment with weekly high-dose 5-fluorouracil and sodium folinic acid (s-FA) (AIO-schedule) as 24h-infusion plus bi-weekly oxaliplatin (ox) in patients with…

Aims: In an interdisciplinary phase II trial performed in the period of 1995–97 and based on a 5-FU monotherapy (AIO schedule) it was possible to achieve both a s. metastatic resection after downsizing in 9 patients (17%) and a R0 resection offering a curative option for 6 patients (11%) out of a total collective of 53 treated patients (Wein et al, Ann Oncol 2001). The objective of this phase II trial is to verify whether a combination therapy based on ox can improve the curative option in terms of a s. metastatic resection in a patient cohort with identical inclusion – and exclusion criteria. Methods: Prospecti…