Characterization of hepatocyte-specific Caspase-8 knockout mice in experimental models of acute liver injury
C Liedtke, J Freimuth, KL Streetz, N Beraza, D Lambertz, N Gassler, D Riethmacher, C Trautwein · Zeitschrift für Gastroenterologie · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background and Aims: Induction of apoptosis in the liver is related to liver injury eventually resulting in liver failure. Caspase-8 is the most upstream-located protease (caspase) involved in apoptosis mediated by Fas, TNF and related death receptors of the TNF superfamily. The aim of this study was to characterize conditional caspase-8 knockout (KO) mice in different models of experimental liver injury. Methods: Conditional caspase-8 KO mice were generated by flanking exons 3–4 with loxP sites and introducing a cre-recombinase transgene under the control of the hepatocyte-specific albumin promoter. For inducti…
