Resistance to chemotherapy

Breast cancer is initially high responsive to chemotherapy, but unfortunately relapses and resistances are critically limiting the success of therapy and affect patient's survival. This plays a decisive role in the in the (neo)-adjuvant setting and has been estimated to cause treatment failure in >90% of patients with metastatic disease. It could be of intrinsic nature or acquired during the course of treatment. In this case, tumors may become resistant to drugs other than those initiating the resistance, despite the fact that these drugs may have different mechanisms of action. Drug resistance may be caused by…