CareLit Fachartikel

TGF-beta alters liver regeneration and ductular reaction via Notch signaling, thus contributing to HBV-associated fibrogenesis

H Weng, L Ciuclan, C Meyer, T Huang, PR Mertens, MV Singer, S Dooley · Zeitschrift für Gastroenterologie · 2009 · Heft 01

Dokument
968543
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
H Weng, L Ciuclan, C Meyer, T Huang, PR Mertens, MV Singer, S Dooley
Ausgabe
Heft 01 / 2009
Seiten
–
Erschienen: 2009-01-20 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1191753

Zusammenfassung

Hepatic progenitor cells (HPC) instead of normal hepatocytes become the main population of regenerative hepatocytes, promoting a periportal ductular reaction (DR), which may contribute to periportal fibrogenesis in chronic liver disease in association with HCV and NASH. We hypothesize that a TGF-b-Notch signaling dependent alteration of the replicative pathway of hepatocytes and a subsequent DR play a critical role in HBV associated fibrogenesis and cirrhosis. 105 biopsied liver tissues with chronic HBV infection were stained with cytokeratin-7 (CK7) to quantify DR and the number of HPCs, and with p21 to assess…

Schlagworte

TGF-beta ductular reaction hepatic progenic cells hepatocyte proliferative arrest portal fibrogenesis Zeitschrift für Gastroenterologie