PD1/PD-L1 protects from inflammation and fibrosis in non-alcoholic steatohepatitis

The pathophysiological mechanisms leading to the development of non-alcoholic steatohepatitis (NASH) remain unclear. There are differences in the susceptibility to NASH between different species and sexes. The aim of this study was to investigate the susceptibility of three different mouse strains to NASH. Methods and Results: NASH was induced in C57BL/6, 129/SvJ and BALB/C male mice (8 weeks old) applying 2 different models: (i) methionine-choline deficient (MCD) diet and (ii) an atherogenic (Ath) diet that has been shown to more accurately resemble pathopyhsiological changes observed in human NASH (Matsuzawa e…