Down-regulation of CXCL1 inhibits growth of colorectal liver metastases

Colorectal cancer is the fourth most abundant type of cancer in the world. Most of the CRC patients die from metastases, predominantly in the liver. Metastasis results from a complex cascade of events, necessitating the involvement of numerous tumor cell–derived factors and microenvironmental molecules, including specific chemokines. In addition to their activities in the haematopoietic context, the possible role of chemokines to regulate tumor growth and metastasis in different ways-either by promoting or inhibiting these processes has motivated us to investigate the hypothesis that chemokines may not only affe…