In patients failing sequential or combination therapy with lamivudine and adefovir switching to adefovir plus entecavir is effective and leads to strong viral suppression in HBV m…

Aims: In patients failing lamivudine or adefovir monotherapy due to suboptimal viral response or development of viral resistance switching or add-on therapy has been the common therapeutical approach used in clinical practice over the last years. Although both approaches often lead to suppression of viral replication, a subset of mainly HBeAg positive patients with highly replicative active HBV remains viremic. These patients have an increased risk of selection of multi-drug resistance viral strains. The aim of this observational cohort study was to investigate the efficacy and safety of the combination of adefo…