The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils

Background and Objective: LL-37 is a human cathelicidin antimicrobial peptide and acts as effector molecule of the innate immune system with direct antimicrobial and immunomodulatory effects. The aim of this study was to test whether Cathelicidin modulates the response of neutrophils to microbial stimulation and improves the neutrophils ability to kill bacteria. Material and Methods: Human neutrophils were isolated from human buffy coat and stimulated with LPS, Staphylococcus aureus and Pseudomonas aeruginosa following preincubation with different concentrations of LL-37, then Cytokine production was measured by…