The Individuality of Tumour-Stroma Interaction in Non-Small Cell Lung Cancer: Insights from Funtional and Molecular Analysis
S Gottschling, M Granzow, R Kuner, A Jauch, E Chang Xu, T Muley, H Hoffmann, H Dienemann, V Eckstein, AD Ho, FJF Herth, M Thomas, M Meister · Pneumologie · 2009 · Heft 03
Bibliografische Angaben
Zusammenfassung
Tumour-stroma interaction plays a significant role for malignant growth. Here, we analyzed the functional and molecular sequels of interaction in a non-contact co-culture model consisting of the lung adenocarcinoma cell lines A549, H23, or H1703 and primary stromal cells (SC) derived from normal lung tissue (NLT) and non-small cell lung cancer (NSCLC) lesions of newly diagnosed NSCLC patients. The behavioural alterations of the tumour cells upon exposure to SC are shown below: Proliferation and colony efficiency Migration Adhesion Invasion Chemosensitivity (cisplatin) NSCLC-SC NLT-SC NSCLC-SC NLT-SC NSCLC-SC NLT…
