Spatial uncertainty associated with stereotaxic coordinates of neuroimaging results

Introduction: Results from functional neuroimaging studies are usually reported as coordinates for local maxima. Consequently, comparison across studies, either in discussions or quantitative meta-analyses, will is almost exclusively be based on those coordinates. The spatial uncertainty associated with stereotaxic coordinates, however, is yet largely unknown. Materials & Methods: Empirical assessment of the spatial uncertainty associated with local maxima was performed based on fMRI data from 21 subjects imaging a simple motor task. Each subject was preprocessed and analysed 9 times, using different approaches…