PET Imaging of Anti-PSMA Antibodies as Novel Agents for Targeting Prostate Cancer
S Wiehr, U Elsäßer-Beile, K Alt, P Bühler, P Wolf, MS Judenhofer, G Reischl, BJ Pichler · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Ziele: The Prostate Specific Membrane Antigen (PSMA) has been shown to represent an excellent target for diagnosis and therapy of prostate cancer. We generated monoclonal antibodies (mAbs) against native cell-adherent PSMA. The aim of the present study was to show the specific binding of these mAbs in human prostate tumors in SCID mice and their use for PET imaging of prostate cancer. Methode: Specific binding of the mAbs to distinct extracellular epitopes of cell-adherent PSMA was determined by flow cytometry. For PET imaging the mAbs and F(ab)2-fragments were conjugated with the chelating agent DOTA and radiol…
