Rat Stroke Models: Evaluation using 3D-micro-CT
A Langheinrich, M Yeniguen, A Ostendorf, S Marhoffer, C Müller, E Stolz, G Bachmann, T Gerriets · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Ziele: Animal models of focal cerebral ischemia are widely used to investigate effects on stroke pathophysiology and evaluation of therapeutic approaches. Therefore, the purpose of our study was to evaluate the feasibility of micro-CT imaging for analysis different models of focal cerebral ischemia in rats. Methode: Focal cerebral ischemia was performed using the macrosphere method (n=4) or the suture technique (n=4) for permanent middle cerebral artery occlusion or the sinus sagittalis superior thrombosis model (n=4) in rats. Using micro-CT (8µm3 voxels), brains were scanned en-bloc after contrast perfusion and…
