The metabolic regulator FGF-21 is induced by free fatty acids but not by PPARχ stimulation in man: Results of two randomized, controlled trials
K Mai, J Andres, J Weicht, S Meinus, T Bobbert, F Reinecke, M Möhlig, M Weickert, A Pfeiffer, J Spranger · Diabetologie und Stoffwechsel · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Objective: Fibroblast growth factor 21 (FGF-21) improves insulin sensitivity and lipid metabolism in obese or diabetic animal models, while human studies revealed increased FGF-21 levels in obesity and type 2 diabetes. Given that FGF-21 has been suggested to be a PPARα-dependent regulator of fasting metabolism, we hypothesized that free fatty acids, natural agonists of PPARα, might modify FGF-21 levels. Furthermore we aimed to evaluate the effect of PPARχ-stimulation on FGF-21 levels. Research design and methods: HepG2 cells were incubated with different fatty acids. Within a randomized controlled trial a 240min…
