Individual stearoyl-CoA desaturase 1 (SCD1) expression modulates ER stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sens…

Objective: Increased plasma levels of free fatty acids occur in obesity and type 2 diabetes and contribute to the development of insulin resistance. Especially saturated fatty acids (SFA) like palmitate have lipotoxic effects leading to endoplasmatic-reticulum (ER) stress, inflammation and insulin resistance. Stearoyl-CoA desaturase 1 (SCD1) plays a key role in preventing lipotoxic effects as it converts SFA to less harmful monounsaturated fatty acids. Here, we tested the hypothesis that individual differences in the regulation of SCD1 expression by palmitate exist and influence the cellular response to palmitat…