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Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia

K Nebral, D Denk, A Attarbaschi, M König, G Mann, OA Haas, S Strehl · Klinische Pädiatrie · 2009 · Heft 05

Dokument
968967
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
K Nebral, D Denk, A Attarbaschi, M König, G Mann, OA Haas, S Strehl
Ausgabe
Heft 05 / 2009
Seiten
–
Erschienen: 2009-05-11 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0029-1222663

Zusammenfassung

Background: PAX5, a master regulator of B-cell development, was shown to fuse to AUTS2, C20orf112, ELN, ETV6, FOXP1, and ZNF521 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). To determine the overall incidence and the whole spectrum of PAX5 fusion partners in childhood ALL a population-based FISH screening study was performed. Patients: 446 children with de novo ALL registered in the Austrian ALL-BFM-2000 and Interfant-99 studies were analyzed. Methods: A dual-color split-apart FISH assay with BAC clones flanking PAX5 was employed. Novel fusion partners were identified by FISH, 3' or 5' RACE, and su…

Schlagworte

Klinische Pädiatrie