Does the exclusion of maternal background risk in calculation software PRC, PIA and JOY improve First Trimester Screening (FTS)?

Aims: In FTS maternal age is integrated into the calculation algorithm as a background risk, which is then modified by nuchal translucency, free ß-hCG and PAPP-A.1 2 This might increase the false positive rate in older, and the false negative rate in younger mothers.3 4 This study analysed the impact in test performance of 3 FTS software programs if the maternal background was excluded. Material and method: In a first step, 1.932 combined FTS with known fetal outcome, collected at the Medical University of Hanover, underwent risk calculation with the software programs Prenatal Risk Calculation (PRC) (Version 1.0…