Morphological integration of newborn neurons in the dentate gyrus after stroke

Neurogenesis continuously adds newborn neurons to the dentate gyrus within the hippocampal network. Under physiological conditions these newborn cells integrate on the morphological and functional level and show similar properties as resident neurons. Only little is known about the integration of newborn neurons in the lesioned brain. Jessberger et. al (2007) previously demonstrated that newborn neurons born after experimental status epilepticus aberrantly integrate into the neuronal circuits in the dentate gyrus. Here, we analyzed the morphological integration of newborn neurons after focal cerebral ischemia. O…