Introducing a methodology to use activities of daily living outcomes in the assessment of the cost-effectiveness of AD treatments: a case study using rivastigmine patch

Objective: Measures of activities of daily living (ADL), as a functional assessment, may be a more accurate payer-relevant reflection of disease burden than cognitive assessments in Alzheimer's disease. The objective of this study is to evaluate the usefulness of ADL instruments in cost-effectiveness modelling in Alzheimer's disease. Methods: A core economic model used Mini Mental State Examination (MMSE) scores from the IDEAL trial, which demonstrated significant benefits for rivastigmine patch over placebo. The model was adapted to include Alzheimer's Disease Cooperative Study Activities of Daily Living Invent…