Leukapheresis and Exchange Transfusion in Children with Acute Leukemia and Hyperleukocytosis. A Single Center Experience
R. Haase, N. Merkel, O. Diwan, K. Elsner, C. M. Kramm · Klinische Pädiatrie · 2009 · Heft 06 · S. 374-378
Bibliografische Angaben
Zusammenfassung
Abstract BACKGROUND: The risk of severe complications or death during the initial period of acute leukemia was markedly decreased due to the progress in pediatric oncology and use of simple measures like hyperhydration, forced diuresis, treatment of hyperuricemia, correction of electrolyte and coagulation disturbances and the careful use of antileukemic drugs. The incidence of leukostasis and tumor lysis syndrome depends on absolute initial white blood cell counts and the underlying type of leukemia. Leukapheresis or exchange transfusion may improve the prognosis of high risk patients. METHODS: Records of all pe…