Fistulas and NOD2 homozygosity are strongly associated with concomitant intestinal stenosis in patients with Crohn's disease
M Jürgens, R Laubender, J Seiderer, B Göke, P Lohse, K Herrmann, T Ochsenkühn, S Brand · Zeitschrift für Gastroenterologie · 2009 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background & aims: We analyzed the prevalence of concomitant intestinal stenosis in patients with fistulizing Crohn's disease (CD), also including the NOD2/CARD15 and IL23R genotype status. Methods: In a retrospective study, medical records of n=1110 patients with inflammatory bowel diseases were screened for patients with fistulizing and stricturing CD. Study inclusion required diagnosis of stenosis made within 6 months of diagnosing fistulas. Similarly, we prospectively investigated 42 patients presenting with fistulizing CD. Patients were genotyped for the three common CD-associated NOD2 mutations (p.R702W, p…
