Lung-specific overexpression of CC chemokine ligand (CCL2) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis
C Winter, K Taut, M Srivastava, F Länger, M Mack, DE Briles, JC Paton, R Maus, T Welte, MD Gunn, UA Maus · Pneumologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Mononuclear phagocytes are critical components of the lung innate host defense to inhaled bacterial pathogens. The monocyte chemotactic protein CCL2 plays a pivotal role in inflammatory mononuclear phagocyte recruitment. Here, we tested the hypothesis that increased CCL2-dependent mononuclear phagocyte recruitment would improve the lung innate host defense to infection with Streptococcus pneumoniae. Results: CCL2 transgenic mice that overexpress human CCL2 protein in type II alveolar epithelial cells and secrete it into the alveolar air space showed a similar proinflammatory mediator response and neu…
