Epithelial-mesenchymal transition of biliary epithelial cells during cholestatic fibrosis
F Schulze, E Konze, K Petmecky, K Schardt, O Dirsch, U Töx, S Schievenbusch, HP Dienes, M Odenthal · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Epithelial-mesenchymal transition (EMT) is a process in which epithelial cell layers lose polarity plus cell-cell contacts and undergo cytoskeleton reorganization. This phenomenon has been observed in the pathogenesis of cancer. In addition, recently, EMT was also shown to be involved in renal fibrosis upon ureteral obstruction. In order to study whether biliary epithelial cells (BEC) are able to undergo EMT during fibrogenesis we analyzed liver tissues in a bile-duct ligation (BDL) model of rats and human liver biopsies with cholestatic fibrosis. Methods: Liver tissue of sham operated and BDL-rats…
