CareLit Fachartikel
Parallel in vitro expansion of human hepatitis C virus specific FoxP3- effector memory and FoxP3+ regulatory CD8+ T cells on recognition of the same antigen
E Billerbeck, HE Blum, R Thimme · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Dokument
971554
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Jahr
2007
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Zusammenfassung
There is growing consensus that regulatory T cells contribute to regulation of T cell responses to tumors and microbes. FoxP3 has been shown to be the most specific marker for regulatory CD4+ T cells, however, itrsquor;s significance in the CD8+ T cell population is less understood. Here we show that the in vitro stimulation of PBMC from chronically HCV infected patients with specific peptides gives rise to two distinct antigen-specific T populations, FoxP3- and FoxP3+ CD8+ T cells. The FoxP3+ virus-specific CD8+ T cells share phenotypical markers of regulatory T cells, such as CTLA–4 and GITRI expression. They…
Schlagworte
CD8+ regulatory T cells
HCV
immune regulation
Antibodies
Population
Cytokines
After
Hepatitis
Zeitschrift für Gastroenterologie
