Early HBV DNA suppression in serum as predictive marker of long-term antiviral efficacy
M Lütgehetmann, K Wursthorn, M Dandri, T Volz, M Zankel, C Fischer, C Brosgart, J Petersen · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and aims: As reported previously (Wursthorn et al, Hepatology 2006; 44: 675–84) 48 weeks of combination therapy with PEG-IFN alfa–2b and Adefovir (ADV) in patients chronically infected with Hepatitis B Virus (HBV) led to reduction of intrahepatocellular cccDNA by –2.4 log and was accompanied by high numbers of HBsAg seroconversion (4/24 patients) and HBeAg loss or HBeAg seroconversion (8/15 HBeAg-positive patients). Maximal early reduction of serum viral load has been associated with improved treatment outcomes and less resistance in HBV patients. The aim of this study was to link early virological re…
