CareLit Fachartikel
Human antigen presenting cells stimulate HBV specific CTL and Th cells in the trimera mouse model
R Vuyyuru, S Herzog-Hauff, S Tavakoli, PR Galle, WO Böcher · Zeitschrift für Gastroenterologie · 2007 · Heft 01
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971556
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Jahr
2007
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Zusammenfassung
Introduction: The strength and breadth of antiviral T cell response is correlated with disease outcome from hepatitis B. Thus, induction of HBV-specific T cells by therapeutic vaccination might represent a new therapeutic strategy, as demonstrated in the humanized trimera mouse model. However, nod.scid mouse derived antigen presenting cells (APC) might reconstitute together with transferred human B cells, monocytes and dendritic cells. Thus, it was hypothesized that murine APC might crosspresent vaccine derived epitopes to human T cells. Methods: To study this issue, Balb/c mice were lethally irradiated, reconst…
Schlagworte
CTL induction
antigen presenting cells
chronic HBV infection
trimera mouse
Cytokines
Antigen-Presenting Cells
Dendritic Cells
Antigens
Cytokine
Hepatitis
Zeitschrift für Gastroenterologie
