Immunologic evidence for lack of heterologous protection following resolution of HCV infection
J Schulze zur Wiesch, J Timm, T Kuntzen, M Neukamm, A Kim, V Kasprowicz, RT Chung, A Lohse, T Allen, G Lauer, B Walker · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Bibliografische Angaben
Zusammenfassung
Chronic HCV infection is typically characterized by a lack of virus-specific CD4+ T-cell proliferative responses, but strong responses have been described in a subset of persons with persistent uncontrolled viremia. One possible explanation for these responses is that they were primed by an earlier resolved infection and do not recognize the current circulating virus. To address this, we defined the targeted epitopes in persons chronically infected with different HCV genotypes (GT), and sequenced the autologous virus present in vivo. HCV-specific CD4+ T cell lines of 44 subjects (24 subjects with current GT1 inf…
