A small surgical injury of subcutaneous adipose tissue up and down regulates expression of genes in epidydimal adipose tissue

Aim: From studies in Siberian hamsters and rats it is known that white adipose tissue is innervated and that surgical denervation of white adipose tissue triggers an increase in fat cell number. We could observe the same phenomenon in rats. A small surgical injury of subcutaneous adipose tissue increased the number of fat cells in epidydimal adipose tissue. This observation prompted us to analyse the gene expression in epidydimal adipose tissue in rats with and without surgical injury of subcutaneous adipose tissue. Methods: mRNA profiling using Affymetrix Gene Chips was carried out in epidydimal adipose tissue…