NOD1 gene E266K (G796A) polymorphism is associated with disease susceptibility but not with disease phenotype or NOD2/CARD15 in Hungarian patients with Crohn's disease
T Molnár, P Hofner, F Nagy, PL Lakatos, S Fischer, L Lakatos, Á Kovács, I Altorjay, K Palatka, P Demeter, Z Tulassay, P Miheller, J Papp, Y Mándi, J Lonovics · Zeitschrift für Gastroenterologie · 2007 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: NOD1/CARD4, a member of the pattern-recognition receptor (PRR) family, is a perfect candidate as a susceptibility gene for Crohn's disease (CD). Since only limited and conflicting data are available on G796A polymorphisms in IBD patients, we set out to study the effect of this polymorphism on the susceptibility and course of CD in the Hungarian population. Methods: 434 unrelated CD patients (age at presentation: 28.6±9.6 years, female/male: 210/224, duration of CD: 8.2±6.9 years) and 200 healthy subjects (blood donors) were investigated. NOD1 G796A was detected by using polymerase chain reaction/restrictio…
