Association of Polymorphisms in the Mannose-Binding Lectin Gene and Pulmonary Morbidity in Preterm Infants
A Hilgendorff, K Heidinger, A Bohnert, I König, C Merz, L Gortner, G Bein · Zeitschrift für Geburtshilfe und Neonatologie · 2007 · Heft 06
Bibliografische Angaben
Zusammenfassung
Objective. The collectine mannose-binding lectine (MBL) plays a significant role in innate immunity and its deficiency has been shown to be a risk factor for pulmonary and systemic infections in children and adults. As previous epidemiological studies described a very strong genetic interference on serum levels of MBL, the aim of this study was to determine the genetic influence of sequence variations within the MBL gene on pulmonary morbidity in preterm infants below 32 weeks gestational age (GA), significantly influenced by infectious complications and inflammatory processes. Materials and Results. Three valid…
