Functional measures in spinocerebellar ataxia (SCA) – evaluation of a SCA Functional Composite Index
T Schmitz-Hübsch, D Timmann-Braun, S Szymanski, S Döhlinger, JS Kang, C Globas, L Schöls, T Klockgether · Aktuelle Neurologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Functional measures are assumed to have superior metric properties as an outcome parameter to assess changes over time. We here report population norms and variability of a Composite Index assessed in 412 SCA patients (genotypes 1,2,3 and 6) in a large multinational trial. The Functional Index is formed of three functional measures: 8m walking time, 9-hole peg test and PATA repetition rate. Whereas PATA rate is found near normally distributed in our study sample (mean 21.7/10s, SD 7.7), time for 8m walk (mean 10.7s, SD 11.8) or 9-hole peg test (mean 47.2s, SD 35.7 in dominant and 52.2s, SD 41.8 in non-dominant h…
