Characterization of Gut Homing properties of circulating T cells in patients with Irritable Bowel Syndrome (IBS)
B Adam, T Liebregts, C Bredack, SM Brierley, KR Pilkington, A Roth, JG Junne, LA Blackshaw, NJ Talley, G Holtmann · Zeitschrift für Gastroenterologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: Inflammation and immune activation may contribute to the manifestation of symptoms in at least a subgroup of patients with IBS. Preliminary studies suggest increased mucosal T cells occurring in a subset of patients with IBS. We have previously demonstrated that peripheral blood lymphocytes from patients with diarrhea- predominant IBS have an augmented cytokine release (Gastroenterology 2007; 132:913–920). Detection of alpha-4 integrin (α4) and beta-7 integrin (β7) on circulating T cells lymphocytes identifies specific lymphocyte subsets trafficking between the circulation and the gut. We therefore hypothe…
