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Methylation of SOCS3 in the carcinogenesis of Barrett's adenocarcinoma

I Stricker, I Tischoff, F Sommerer, M Vieth, A Tannapfel · Zeitschrift für Gastroenterologie · 2007 · Heft 09

Dokument
973171
CareLit-ID
Jahr
2007
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
I Stricker, I Tischoff, F Sommerer, M Vieth, A Tannapfel
Ausgabe
Heft 09 / 2007
Seiten
–
Erschienen: 2007-09-05 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2007-988343

Zusammenfassung

Aims: This study was performed to elucidate the role of SOCS1 and SOCS3 in Barrett's adenocarcinomas and its precursor lesion. Methods: Methylation of SOCS1 and SOCS3 was analysed using methylation-specific PCR (MSP) in 19 Barrett's adenocarcinomas, 56 Barrett's intraepithelial neoplasias (19 low and 27 high grade), 30 Barrett's mucosas without neoplasia and 20 samples of normal squamous epithelium as well as gastric mucosa. The mRNA transcript expression was confirmed by semiquantitative RT-PCR. Protein expression was investigated by immunhistochemistry. Results: SOCS3 hypermethylation was found in 14/19 (74%)…

Schlagworte

Zeitschrift für Gastroenterologie