Poor outcome in shock induced progressive sclerosing cholangitis

Aims: Progressive sclerosing cholangitis is a severe liver disease which we described in 2003 (Engler et al. Gut 2003;52:688–693). We evaluated the outcome after long-term follow-up of 29 patients treated in our institution between 1995 and 2007. Methods: Patients with cholestatic liver disease without evidence of pre-existing hepatobiliary disease who previously required long-term treatment in an intensive care unit for septic shock due to following reasons: severe trauma (n=10, 5 burn injury and 5 accident), cardiac operation (n=9), bacterial infection (n=5), sigmoidectomy (n=2), operation of aortic aneurysm (…