Histological NASH Score (NAS) Correlates with M30 Immune Expression in Obese Patients undergoing Bariatric Surgery
L Bechmann, M Schlensak, I Wedemeyer, N Wiesemann, M Odenthal, HP Dienes, J Erhard, G Gerken, J Erhrad, A Canbay · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Bariatric surgery (i.e. gastric banding; gastric bypass) is an effective therapeutic approach in morbidly obese patients (BMI >40). Apoptosis is believed to play a crucial role in the pathogenesis of non-alcoholic steatohepatitis (NASH). The extent of apoptosis could be measured by assessing M30 immune expression. NAS scoring system is a newly established method to assess the extent of steatosis including scores for ballooning, inflammation and steatosis (NAS 2–3: suspicious of NASH; NAS 5–8: NASH). Methods: 30 morbidly obese patients (BMI: 54.8±8.5; age: 39±8.6; 12 males, 18 females), who underwent bariat…
