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Regulation of the CD95 gene by the p53 family network- the intronic binding site is essential

AE Schulze Schleithoff, A Kairat, AF Koch, W Stremmel, PH Krammer, M Müller · Zeitschrift für Gastroenterologie · 2008 · Heft 01

Dokument
973489
CareLit-ID
Jahr
2008
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
AE Schulze Schleithoff, A Kairat, AF Koch, W Stremmel, PH Krammer, M Müller
Ausgabe
Heft 01 / 2008
Seiten
–
Erschienen: 2008-01-23 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2008-1037533

Zusammenfassung

Introduction: The p53 family members p63 and p73 give rise to proteins that have p53-agonistic as well as p53-antagonistic functions. p63 and p73 express two main classes of isoforms: isoforms which contain the transactivation domain (TAp73 and TAp63) and dominant negative isoforms (DeltaNp63 and DeltaNp73) acting as operant inhibitors of TAp73, TAp63 and wild-type (wt) p53. We aimed to provide insight into the molecular mechanisms of the regulation and transactivation of the CD95 gene by the p53 family. Methods: 1. Identification of the p53 binding site in intron 1 and three p53 binding sites in the promoter of…

Schlagworte

CD95 apoptosis p53 p63 p73 Zeitschrift für Gastroenterologie