p16 protein expression in the liver: an immunohistochemical study

Background & Aim: The product of the CDKN2A gene is an essential regulator of cell cycle controlling the entry of cells into the S-phase and is reported to be involved in the hepatocarcinogenesis. Herein, we evaluated p16 protein expression in patients with liver tumors. Patients & Methods: 148 tissue sections were obtained from 81 patients [hepatocellular carcinoma (HCC; n=36), liver metastasis (n=25), cholangiocellular cancer (CCC; n=8), and benign liver tumors (n=4) and chronic hepatitis C (n=8)] and were studied by immunohistochemistry for p16 protein expression. p16 expression was graded using our ImmunoRea…