Cytochrome P4502E1 is responsible for miscoding etheno-Dna adducts induced by ethanol in the liver

Chronic alcohol consumption leads to hepatic cirrhosis and hepatocellular cancer (HCC) possibly via oxidative stress. Ethanol induces cytochrome P4502E1 (CYP2E1) resulting in the generation of reactive oxygen species (ROS) which cause lipidperoxidation. Lipid peroxidation products such as 4-hydroxynonenal (4HNE) can finally react with DNA forming exocyclic etheno-DNA adducts with high mutagenic and carcinogenic properties (1). Such adducts have been detected in hepatic biopsies from patients with alcoholic liver disease (ALD) (2). To study whether alcohol metabolism via CYP2E1 results in the generation of 1,N6-e…