Neurophysiological evidence of corticospinal tract dysfunction in Wilson's disease

Introduction: Wilson's disease is a rare autosomal recessive disorder of hepatic copper transport leading to a biliary excretion inhibition of copper. Overload of the metal mainly in liver and basal ganglia leads to hepatic but also to extrapyramidal motor clinical symptoms. However, involvement of the corticospinal system is hardly known. Methods: To study corticospinal tract dysfunction in Wilson's disease motor evoked potentials (MEP) were performed in 42 patients (14 with a non-neurological and 28 with a neurological form) with Wilson's disease undergoing long-term treatment. F-wave method was used to determ…