Voluntary movement execution in Huntington's disease: A combined neurophysiological and morphometric magnetic resonance imaging study

Huntington's disease is an autosomal dominant neurogenetic disorder leading to striatal atrophy. Characteristic for HD are choreatic involuntary movements, but also voluntary movements deteriorate, but the neurophysiological mechanisms are less understood. In this study we investigated voluntary movement execution by means of movement-related potentials (MRPs) in symptomatic HD (HD) and presymptomatic HD (pHD) and healthy controls. Additionally, voxel-based morphometry (VBM) was applied to assess a possible relation of neurophysiological and neuroanatomical alterations in HD. Reaction times (RTs) were slower in…