Effects of antidepressive therapy on auditory processing on auditory processing in severely depressed patients: A combined MRS and MEG study

Introduction: Alterations in brain metabolism as well as in brain function in different brain areas can be observed in severely depressed patients. For example, severely depressed patients often report disturbed sensoric perception. The present study combined proton magnetic resonance spectroscopy (1H-MRS) and magnetoencephalography (MEG) of the left auditory cortex in severely depressed inpatients pre and post successful antidepressive therapy. The aim of this study was to assess functional and metabolic alterations of auditory processing during a depressive episode before and after treatment. It was hypothesis…