Interdendritic cell transmission of peptides and costimulatory molecules

Dendritic cells are located around the airways and in the loose connective tissue around the vessels and in the pleura, realizing a tight surveillance network. They are in a resting or immature state. After encountering foreign particles or pathogens, they are stimulated by the delivered danger signals. When they are activated, classical or conventional dendritic cells will bring foreign antigens to the lymph nodes to prime T cells. Primed T cells will migrate towards other lymphoid organs of the body and in the lung in form of memory T cells. Lately, it has been shown that the local milieu, generated by epithel…