Effect of a cross-linked cellulose-containing weight-loss supplement on gastric emptying and sensory functions in obese subjects

Aims: CM3, a weight-loss supplement consisting of highly cross-linked cellulose, is applied in a capsule-form and expands in the stomach to a size up to 18-fold of its original. It is advertised as inducing an immediate feeling of satiety and delaying gastric emptying, thus supporting weight loss management. Its putative mechanism of action is unclear. Purpose of the study was to examine if CM3 delays gastric emptying (using the stable isotope 13C octanoic breath test) and influences subjective feelings of appetite sensations (using anchored visual analogue scales, VAS) after a standardized solid meal. Design an…