Role of wnt-5a in the determination of human mesenchymal stem cells to preadipocytes

Aims: Increasing adipocyte size as well as numbers is important in the development of obesity, with adipocytes being generated from mesenchymal precursor cells. This process comprises the determination from mesenchymal stem cells (MSC) into preadipocytes (PA) and the differentiation of PA into mature fat cells. While the process of differentiation is highly investigated, the determination from MSC to PA in humans is poorly understood. Therefore, in the present study we have examined the role of different wnt molecules in the process of determination of human MSC into PA. Methods: Human MSC were prepared from umb…