Mammographic density in breast cancer patients and polymorphisms in the estrogen pathway

Fragestellung: Breast density is an important parameter in relation to risk factors for breast cancer. It is not only associated with an increased risk of breast cancer, but also directly influences the selection of patient groups for scientific studies, as it influences the sensitivity and specificity of mammography. Hormone replacement therapy has also been reported to influence the risk of breast cancer and mammographic density. Furthermore mammographic density seems to be inheritable. Therefore we wanted to correlate genetic polymorphisms that influence the estrogen pathway with mammographic density in a coh…