The bioactivity of multidrug resistance transporter proteins is increased in human esophagus cancer-derived myofibroblasts

Background and aims: The expression of multi-drug resistance (MDR) transporter genes can cause the ineffectiveness of chemotherapeutics for the treatment of cancer. Our aim was to investigate the bioactivity of MDR proteins in human normal (NM) and esophagus cancer-derived myofibroblasts (CDM). Methods: Myofibroblasts were isolated from surgically resected esophageal cancers and adjacent “normal“ tissue. “Normal“ tissues adjacent to esophageal tumors were taken from macroscopically normal esophageal mucosa at least 2cm from the tumor margin. The bioactivity of MDR transporters was measured using the fluorescence…