Interaction between seroreactivity to microbial antigens and genetics in Crohn's disease: is there a role for defensins?
S Fischer, M Papp, I Altorjay, Y Mandi, L Lakatos, J Tumpek, A Kovacs, T Molnar, Z Tulassay, P Miheller, K Palatka, T Szamosi, J Papp, P Lakatos, , Hungarian IBD Study Group · Zeitschrift für Gastroenterologie · 2008 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Antibodies against different microbial epitopes are associated with disease phenotype, may be of diagnostic importance, and may reflect a loss of tolerance in Crohn's disease (CD). Recently, an association was reported between the presence of these antibodies and mutations in pattern receptor genes. Our aim was to investigate whether mutations in various genes other than NOD2/CARD15 or TLR4 associated with CD (NOD1/CARD4, DLG5, and DEFB1) may influence the presence of antibodies against bacterial proteins and carbohydrates in a Hungarian cohort of CD patients. Methods: 376 well-characterized, unrelat…
