NFKBIA 3'UTR and NFKB1–94ins/delATTG variants in Hungarian IBD patients: the 3'UTR variant is associated with extensive colitis
T Szamosi, A Szilvasi, L Lakatos, A Kovacs, T Molnar, I Altorjay, M Papp, O Szabo, A Satori, Z Tulassay, P Miheller, J Papp, A Tordai, H Andrikovics, P Lakatos · Zeitschrift für Gastroenterologie · 2008 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Nuclear factor kappa-B (NF-kB) plays a crucial role in diseases associated with dysregulated immune response. NFkB inhibitor alpha downregulates the activity of NFkB. In previous studies the NFKBIA 3'UTR AA genotype was associated with CD, while the NFKB1–94ins/delATTG mutation increased the risk for UC. Our aim was to study the above polymorphisms and patients' response to medical therapy and/or disease phenotype in Hungarian IBD patients. Methods: 415 unrelated IBD patients (CD: 266, age: 35.2±12.1 years, duration:8.7±7.5 years and UC: 149, age: 44.4±15.4 years, duration:10.7±8.9 years) and 149 hea…
