microRNA-29 Regulates the Expression of Profibrogenic Mediators in Hepatic Stellate Cells
M Kwiecinski, A Noetel, S Schievenbusch, I Strack, N Elfimova, U Drebber, U Töx, HP Dienes, M Odenthal · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: microRNAs (miRNAs) are short noncoding, endogenous RNAs that posttranscriptionally regulate gene expression by targeting the 3´-untranslated regions (3´UTR) of mRNAs resulting in RNA degradation or translational repression. Recently, we have shown that miR-29a and miR-29b inhibit collagen expression. In the present study, we now investigated the role of miRNA-29 in profibrogenic growth factor expression as a central mechanism of fibrosis. Methods: miR-29 expression was analysed by Real Time PCR in rat livers after four weeks bile-duct obstruction and in 84 human biopsies with chronic hepatitis C, represent…
