CareLit Fachartikel
Neuronal microRNA participate in myofibroblastic differentiation by targeting the pluripotency factor Lin-28
A Noetel, I Strack, M Kwiecinski, M Scheffler, HP Dienes, M Odenthal · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Dokument
974435
CareLit-ID
Jahr
2010
Publikation
PDF
nein
Metadaten
DOI
ja
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Zusammenfassung
Hepatic Stellate Cells (HSC) transdifferentiate into myofibroblastic cells, which are the main producers of extracellular matrix components in hepatic fibrogenesis. Myofibroblastic transition is associated with an altered profile of growth factors and mediators of inter- and intracellular cell communication. Small non-coding, so called microRNAs (miRNA) participate in regulation of gene expression by interaction with the untranslated region (UTR) of many transcripts and subsequent inhibition of translation. Thus, they are involved in many cellular processes such as differentiation, carcinogenesis and apoptosis.…
Schlagworte
fibrogenesis
gene regulation
microRNA
neuronal mediators
pluripotency
Zeitschrift für Gastroenterologie
