Role of microRNA-199a-5p and discoidin domain receptor 1 for human hepatocellular carcinoma invasion
V Cicinnati, Q Shen, S Iacob, F Weber, CG Klein, G Sotiropoulos, A Radtke, A Paul, G Gerken, S Beckebaum · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Micro-ribonucleic acid (miRNA)-199a-5p has been reported to be down-regulated in hepatocellular carcinoma (HCC). Discoidin domain receptor-1 (DDR1) tyrosine kinase, involved in cell invasion-related signaling pathway, is predicted to be a potential target of miR-199a-5p by the use of miRNA target prediction algorithms. The aim of this study was to investigate the role of miR-199a-5p and DDR1 in HCC. Material and Methods: Mature miR-199a-5p and DDR1 expression were evaluated in tumor and adjacent non-tumor liver tissues from 23 patients with HCC undergoing liver resection and in five hepatoma cell lines by…
